Darrell Goulding scored twice as resurgent Wigan produced a strong second-half showing to pile on the misery for troubled Engage Super League champions Leeds with a 24-4 victory.
George Carmont and Joel Tomkins also got on the scoresheet as the competition's early leaders claimed a hard-fought win over the injury-ravaged Rhinos at the DW Stadium.
The match had been deadlocked at 0-0 for 34 minutes until Carmont found his way through for the opener. Leeds - who were aggrieved to have had an earlier try ruled out by the video referee - replied through Ryan Hall early in the second half, but that merely prompted Michael Maguire's impressive new Wigan outfit to turn up the heat and they powered to victory.
Chris Riley scored a hat-trick as Warrington Wolves returned to winning ways with an emphatic 32-16 victory over Wakefield Trinity Wildcats.
Warrington - whose three-game winning streak came to an end against St Helens last week - were clearly the superior side in the first half with Riley twice going over in the left corner and further tries for Chris Bridge and Ryan Atkins.
Tries from Michael Korkidas and Aaron Murphy gave the visitors hope of a second half comeback. But - despite Sam Obst's crossing for Wakefield - the hosts overran their opponents with Riley claiming his third try, Atkins grabbing a second and Bridge adding a conversion to his three successful kicks in the first half.
Bradford ground out a hard-fought 19-12 victory over rock-bottom Harlequins - but they were made to work every inch of the way for it.
The visitors led through Chris Melling's 13th-minute score but the Bulls responded immediately through Michael Platt and Brett Kearney edged them in front shortly before the break.
Castleford recorded their first home win of the season with a 22-16 victory over Crusaders at The Jungle.
Their last win on home soil came when they beat the same opponents in September of last year. Tries from Kirk Dixon, Ryan McGoldrick and Joe Westerman put the Tigers in a commanding position at the break. Westerman added a penalty after the break but tries from Jason Chan and Weller Hauraki sandwiched a Jordan Thompson score and made for a nervy finish.